During the fourth industrial revolution, many industries face the challenge of deep adjustments and building new business models. One of them is the insurance sector. The aim of this article is to examine the adjustment of the insurance industry to the process of autonomization of cars. The study was conducted on the basis of a review of current scientific and specialist publications as well as analytical reports dealing with the issues of automated mobility. The transition to automated mobility will systematically increase the importance of new risks while reducing the impact of behavioral risk. The above process creates a number of challenges (including human resources, management, legal) that will have to be addressed by both insurance companies and representatives of public authorities. The article identifies new areas and business opportunities important from the point of view of enterprises.