The use of drones in urban logistics is currently an area of intensive scientific research and technological development. The article focuses on the analysis of the possibility of using unmanned aerial vehicles in urban logistics. The article consists of three parts. In the first one, the authors presented the results of a query of publications, reports and statistical data illustrating the state of knowledge on the development and use of unmanned aerial vehicles in Poland and in the world. Real examples of their use are presented. In the second part, with the help of analysis and synthesis, they focused on the challenges and opportunities resulting from the implementation of drones in urban agglomerations, with particular emphasis on logistics, including last mile logistics. The authors identified the benefits of shortening delivery times, reducing delivery costs, and minimizing environmental pollution in congested cities. They included issues related to the broadly understood security of cities and their inhabitants among the challenges. In the third part of the article, using methods such as abstraction and inference, the perspective of urban development using drones is discussed. According to the authors, the cities of the future will be filled with unmanned aerial vehicles, synchronized with 5G technology, artificial intelligence, the Internet of Things and machine learning. The aim of the article was to present a holistic perspective on the use of drones in urban logistics and to indicate the directions of further research aimed at the optimal use of this technology in urban logistics.